Radiation sensitive liposomes

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United States of America Patent

PATENT NO 8535712
APP PUB NO 20130053618A1
SERIAL NO

13609058

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The present invention relates to a radiation sensitive liposome, and the use of this liposome as carrier for therapeutic and diagnostic agent(s). In particular, the invention encompasses a liposomal delivery system, comprising a stable liposome-forming lipid and a polymerizable colipid, a fraction of which polymerizable colipid polymerizes upon exposure to ionizing radiation, thereby destabilizing the liposomal membrane. Destabilization of liposomes allows for leakage of liposomal contents. The present invention further contemplates methods of diagnosing and treating conditions and diseases that are responsive to liposome-encapsulated or associated agents.

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Patent Owner(s)

  • THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA;VARIAN MEDICAL SYSTEMS, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bondurant, Bruce Tucson, US 6 37
McGovern, Kathy A Tucson, US 5 23
O'Brien, David F Tucson, US 11 120
Sutherland, Robert Menlo Park, US 18 222

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