Thrombin substrate and assay for determining the level of bioactive thrombin in a sample
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United States of America Patent
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Sep 17, 2013
Grant Date -
Jul 22, 2010
app pub date -
Jul 15, 2009
filing date -
Jul 16, 2008
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Abstract
Substrates for thrombin and assays for determining the level of bioactive thrombin in a sample are disclosed, wherein the substrate has the general formula: A-X—Z-A′ wherein one of either A or A′ comprises a luminescent chelate and the other one of A or A′ comprises a first partner of a binding pair, X forms a tri- or tetra-peptide, and Z comprises a linker.
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