Saponin compounds, methods of preparation thereof, use thereof and pharmaceutical compositions
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United States of America Patent
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Oct 8, 2013
Grant Date -
Dec 22, 2011
app pub date -
Feb 8, 2010
filing date -
Feb 9, 2009
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Abstract
This invention relates to novel saponin compounds of formula II wherein MBz denotes p-methoxybenzoyl, and R is selected from the group comprising C6-10 aryl, C6-10 aryl-C1-4 alkyl-, C1-18 alkanoyl, C3-18 alkenyl, C6-10 aryl-C(O)—, C6-10 aryl-C1-4 alkyl-C(O)—, wherein each of the groups can optionally be substituted. These compounds possess a selective cytostatic activity, useful, e.g., in the treatment of proliferative diseases. The invention further relates to methods of preparation of the novel compounds and to a pharmaceutical composition containing these compounds.
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