Expression vector for establishing highly productive cell and the highly productive cell
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United States of America Patent
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Oct 8, 2013
Grant Date -
Nov 17, 2011
app pub date -
Jun 4, 2010
filing date -
Jun 5, 2009
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Abstract
The present invention provides an expression vector which is effective in an efficient establishment of transformed cells which express the aimed protein gene in a high level. An expression vector which has a cassette for expressing the drug selective marker gene containing mRNA destabilizing sequence, at least one element for stabilizing the gene expression and a cassette for expressing the gene of the aimed protein. Preferably, the mRNA destabilizing sequence is derived from AT-rich sequence existing in the 3′-untranslated region of cytokine, interleukin or proto-oncogene, and the element for stabilizing the gene expression is derived from Chinese hamster genome.
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