End-modified poly(beta-amino esters) and uses thereof

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United States of America Patent

PATENT NO 8562966
APP PUB NO 20120149630A1
SERIAL NO

13312224

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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Poly(beta-amino esters) are end-modified to form materials useful in the medical as well as non-medical field. An amine-terminated poly(beta-amino ester) is reacted with an electrophile, or an acrylate-terminated poly(beta-amino ester) is reacted with a nucleophile. The inventive end-modified polymers may be used in any field where polymers have been found useful including the drug delivery arts. The end-modified polymers are particularly useful in delivery nucleic acids such as DNA or RNA. The invention also provides compositions including the inventive end-modified polymers, methods of preparing the inventive polymers, and method of using the inventive polymers.

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Patent Owner(s)

  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Anderson, Daniel Griffith Sudbury, US 83 2229
Langer, Robert S Newton, US 623 35584
Zugates, Gregory T Cambridge, US 43 428
Zumbuehl, Andreas Cambridge, US 14 721

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