Convergent synthesis of renin inhibitors and intermediates useful therein

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United States of America Patent

PATENT NO 8563279
SERIAL NO

12810220

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Described is a method for the preparation of renin inhibitors such as aliskiren, and intermediates useful therein. The method introduces a nitrogen-containing intermediate such as a lactone of formula (8). with R4 being a branched C3—6 alkyl. In the preparation of the lactone, or related intermediates, a desired stereochemical configuration can be controlled by starting from a chiral aldehyde satisfying formula (10).

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DPX HOLDINGS B VHERENGRACHT 483 AMSTERDAM

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Boogers, Jeroen Antonius Franciscus Maastricht, NL 4 3
Broxterman, Quirinus Bernardus Munstergeleen, NL 16 91
Castelijns, Anna Maria Cornelia Francisca Spaubeek, NL 12 8
De, Lange Ben Munstergeleen, NL 28 8
De, Vries Andreas Hendrikus Maria Maastricht, NL 19 6
De, Vries Johannes Gerardus Maastricht, NL 24 22

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