Methods and compositions for gene inactivation

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United States of America Patent

PATENT NO 8569253
APP PUB NO 20120309091A1
SERIAL NO

13068348

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Abstract

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Disclosed herein are methods and compositions for inactivating CCR-5 genes, using zinc finger nucleases (ZFNs) comprising a zinc finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding ZFNs, vectors comprising polynucleotides encoding ZFNs, such as adenovirus (Ad) vectors, and cells comprising polynucleotides encoding ZFNs and/or cells comprising ZFNs are also provided.

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Patent Owner(s)

  • SANGAMO BIOSCIENCES, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ando, Dale Walnut Creek, US 17 392
Holmes, Michael C Oakland, US 87 3629
Lee, Gary Ka Leong San Leandro, US 10 358

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