Process for decellularizing soft-tissue engineered medical implants, and decellularized soft-tissue medical implants produced
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United States of America Patent
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Nov 5, 2013
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Oct 8, 2010
filing date -
Jun 7, 1999
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Abstract
The invention provides methodologies and apparatus for producing a cellular soft-tissue implants, both in small quantities and in commercializable quantities. Such soft-tissue implants include vascular graft substitutes. An acellular graft is produced by subjecting the tissue sample to an induced pressure mediated flow of an extracting solution, followed by inducing a pressure mediated flow of a treating solution, then washing the treated tissue to produce the acellular graft. The acellular grafts produced are uniform and nonimmunogenic.
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