SGLT-2 inhibitors, methods of making them, and uses thereof

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United States of America Patent

PATENT NO 8575114
APP PUB NO 20110237527A1
SERIAL NO

13052171

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Abstract

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The present invention relates to compounds which are inhibitors of sodium dependent glucose co-transporter-2 (SGLT-2). These compounds are used in the treatment of various disorders, including diabetes, impaired glucose tolerance, insulin resistance, retinopathy, nephropathy, neuropathy, cataracts, hyperglycemia, hyperinsulinemia, hyperchlolesterolemia, elevated blood level of free fatty acids or glycerol, hyperlipidemia, hypertriglyceridemia, obesity, wound healing, tissue ischemia, atherosclerosis, and hypertension. These compounds and compositions are also useful for treating and preventing kidney stones, hyperuricemia, gout, and hyponatremia. Methods of making these compounds are also described in the present invention.

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Patent Owner(s)

Patent OwnerAddress
APOLLO ADMINISTRATIVE AGENCY LLC AS SUCCESSOR AGENT9 WEST 57TH STREET NEW YORK NY 10019

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Guo, Cheng Schenectady, US 67 757
Liu, Shuang Schenectady, US 193 1607

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