Synthesis and use of 2′-substituted-N6-modified nucleosides

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United States of America Patent

PATENT NO 8575331
APP PUB NO 20110196144A1
SERIAL NO

12876997

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Abstract

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An improved method of preparing a sugar modified nucleoside analog includes a protocol in which a hydroxy group of a sugar is selectively deprotected and oxidized prior to nucleophilic modification of the corresponding carbonyl group. The modified sugar is then coupled to a heterocyclic base that is modified with a dual nucleophilic reagent in a further step that provides N6-modified adenosine analogs with high stereoselectivity.

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  • VALEANT PHARMACEUTICALS NORTH AMERICA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
An, Haoyun Carlsbad, US 28 549
Ramasamy, Kanda Aliso Viejo, US 9 277
Shaw, Stephanie Rowland Heights, US 9 70

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