[1,2,4]triazolo [1,5-c]pyrimidine derivatives as Hsp90 modulators

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United States of America Patent

PATENT NO 8580783
APP PUB NO 20120184546A1
SERIAL NO

13394255

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Abstract

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The present invention relates to [1,2,4]triazolo[1,5-c]pyrimidine derivatives of formula (I) which inhibit the activity of Heat Shock Protein Hsp90. The compounds of the invention are therefore useful in treating proliferative diseases such as cancer and neurodegenerative diseases. The present invention also provides processes for preparing these compounds, methods of treating diseases and the pharmaceutical compositions comprising these compounds.

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NERVIANO MEDICAL SCIENCES S R LVIALE PASTEUR 10 NERVIANO (MI) I-20014

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Casale, Elena Somma Lombardo, IT 9 40
Casuscelli, Francesco Dairago, IT 17 47
Dalvit, Claudio Milan, IT 10 77
Polucci, Paolo Cassina Rizzardi, IT 21 147
Zuccotto, Fabio Milan, IT 16 169

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