Method for modulating, treating and/or preventing metabolic syndrome using MAS-G-protein-coupled receptor agonists

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United States of America Patent

PATENT NO 8586054
APP PUB NO 20090221498A1
SERIAL NO

12298351

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Abstract

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The present invention is characterized by the use of Mas-G-protein-coupled receptor agonists for the control, prevention and treatment of the body levels of triglycerides, cholesterol and glucose, as well as of hyper-tension and possible increase in body weight, which are characteristic of the clinical manifestation of the metabolic syndrome and its complications. Another characteristic of the invention is the use of Mas-G-protein-coupled receptor agonists, including the Angiotensin-(1-7) peptide and its analogs, agonists, either peptidic or non-peptidic, as modulators of the manifestations of insulin resistance and glucose intolerance and in the prevention and treatment of the related alterations. The invention claims the use of MAS-G-protein-coupled receptor agonists, formulated with pharmaceutically and pharmacologically acceptable excipients or carriers, and Mas-G-protein-coupled receptor agonists, including the Angiotensin-(1-7) peptide and its analogs, agonists, either peptidic or non-peptidic, as modulators of the metabolic syndrome, the diseases that compose it and its complications.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSIDADE FEDERAL DE MINAS GERAISAV ANTONIO CARLOS 6627 REITORIA 7 ANDAR SALA 7005 CAMPUS UFMG - PAMPULHA BELO HORIZONTE MG 31270-901
MAX-DELBRUCK-CENTRUM FUR MOLEKULARE MEDIZINBERLIN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alenina, Natalia Berlin, DE 2 4
Alvarez, Leite Jaqueline Isaura Belo Horizonte, BR 1 4
Bader, Michael Berlin, DE 16 77
Matos, De Moura Marina Belo Horizonte, BR 1 4
Rodriques, Fernandez Luciana Belo Horizonte, BR 1 4
Sinisterra, Rubens Dario Belo Horizonte, BR 1 4
Siqueira, Haibara Andrea Belo Horizonte, BR 1 4
Sousa, Santos Sergio Henrique Belo Horizonte, BR 1 4
Souza, Dos Santos Robson Augusto Belo Horizonte, BR 6 29

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