Method for selectively modifying a protein via transglutaminase catalyzed reaction
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United States of America Patent
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Nov 19, 2013
Grant Date -
Nov 3, 2011
app pub date -
Aug 25, 2008
filing date -
Aug 24, 2007
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Abstract
The present invention relates generally to a novel method of introducing property modifying groups to a protein. In particular, the present invention relates to the derivatization of lysine residues, as well as new conjugates of growth hormones with improved pharmacological properties, and methods for their preparation and use in therapy.
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