Design, synthesis and functional characterization of rottlerin analogs

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United States of America Patent

PATENT NO 8586768
APP PUB NO 20110112182A1
SERIAL NO

12945180

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Abstract

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A method of synthesizing rottlerin analogs is described. The synthesis methods described are the first known method of synthesizing rottlerin analogs from commercially-available materials to produce cost effective analogs. Rottlerin analog structures made by the synthesis methods and methods of use for treating a neurological or inflammatory response mediated by protein kinase C (PKC) are further described.

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Patent Owner(s)

  • IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Anantharam, Vellareddy Gilbert, US 2 5
Kanthasamy, Anumantha G Ames, US 10 16
Kraus, George A Ames, US 30 65

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