Recombinant fusion protein and polynucleotide construct for immunotoxin production
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United States of America Patent
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Dec 3, 2013
Grant Date -
Mar 29, 2012
app pub date -
Sep 22, 2011
filing date -
May 10, 2007
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Abstract
The present invention relates to a polynucleotide construct encoding a fusion protein consisting of a domain which binds the immunoglobulin Fc region, genetically fused to a truncated form of Pseudomonas exotoxin A (PE). In particular, the invention discloses the fusion protein, ZZ-PE38, and further provides immunotoxins, formed from complexes of the fusion protein with antibodies for targeted cell killing.
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