HIV-1 envelope glycoprotein oligomer and methods of use

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United States of America Patent

PATENT NO 8597658
APP PUB NO 20100316661A1
SERIAL NO

12742272

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Abstract

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This invention relates to fusion polypeptides comprised of a trimerization domain fused to a non-membrane bound, non-cleaved gp160 polypeptide derived from the R2 HIV-1 Env glycoprotein and to compositions comprising the fusion polypeptides. This invention further relates to oligomers of the fusion polypeptides. This invention also relates to nucleic acids encoding the fusion polypeptides. This invention also relates to diagnostic and therapeutic methods using the fusion polypeptides. Further, this invention relates to the induction of cross-reactive neutralizing antibodies against HIV-1, and to immunogenic compositions for the prevention and treatment of infection by HIV-1.

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Patent Owner(s)

Patent OwnerAddress
THE HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE INC6720A ROCKLEDGE DRIVE SUITE 100 BETHESDA MD 20817

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Broder, Christopher Silver Spring, US 13 56
Quinnan, Gerald Rockville, US 3 4

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