Methods of characterizing small nucleic acid molecules
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United States of America Patent
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Dec 3, 2013
Grant Date -
Apr 14, 2011
app pub date -
Oct 8, 2009
filing date -
Oct 8, 2009
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Abstract
The invention generally relates to methods of characterizing small nucleic acid molecules, such as plasmids or nucleic acid molecules obtained from a virus. In certain embodiments, the invention provides a method of characterizing a small circular nucleic acid molecule, the method including performing rolling circle amplification on a small circular nucleic acid molecule, thereby producing a concatamer, and generating an optical map of the concatamer, thereby characterizing the small circular nucleic acid molecule.
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