Molecules that selectively home to vasculature of pre-malignant dysplastic lesions or malignancies
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United States of America Patent
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Dec 3, 2013
Grant Date -
Jan 6, 2011
app pub date -
Mar 26, 2010
filing date -
Oct 21, 2003
priority date (Note) -
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Abstract
The present invention provides a conjugate that contains a therapeutic moiety linked to a homing peptide or peptidomimetic which selectively homes to vasculature of pre-malignant dysplastic skin and which includes the amino acid sequence SRPRR (SEQ ID NO: 1) or a conservative variant or peptidomimetic thereof. The present invention further provides a conjugate containing a therapeutic moiety linked to a homing peptide or peptidomimetic which selectively homes to vasculature of malignant skin and which includes the amino acid sequence CGKRK (SEQ ID NO: 6) or the amino acid sequence CDTRL (SEQ ID NO: 7), or a conservative variant or peptidomimetic of one of these sequences.
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