Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
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United States of America Patent
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Dec 10, 2013
Grant Date -
Feb 3, 2005
app pub date -
Nov 4, 2003
filing date -
Nov 5, 2002
priority date (Note) -
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Abstract
The present invention provides compositions comprising at least one oligomeric compound comprising an alternating motif and further include a region that is complementary to a nucleic acid target. The compositions are useful for targeting selected nucleic acid molecules and modulating the expression of one or more genes. In preferred embodiments the compositions of the present invention hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA. The present invention also provides methods for modulating gene expression.
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