Method for orthopoxvirus production and purification

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 8609392
APP PUB NO 20120058539A1
SERIAL NO

13319874

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Abstract

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The present invention relates to a method for producing and purifying a wild type, an attenuated and/or a recombinant Orthopoxvirus. The present invention relates to a purified wild type, attenuated and/or recombinant Orthopoxvirus obtained by the method of the invention and to a pharmaceutical composition, preferably a vaccine, comprising said purified Orthopoxvirus for the treatment and/or the prevention a cancer, an infectious disease and/or an autoimmune disorder, and uses thereof. The present invention also relates to the use of an immortalized avian cell line obtained from an avian cell belonging to the Anatidae family, in particular Cairina moschata immortalized avian cell lines comprising a nucleic acid sequence coding a telomerase reverse transcriptase (TERT) and optionally an E1A nucleic acid sequence, for the production of a wild type, attenuated and/or recombinant Orthopoxvirus according to the process of the invention.

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Patent Owner(s)

  • TRANSGENE S.A.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Campourcy, Sylvie Strasbourg, FR 2 1
Cordier, Yves Strasbourg, FR 9 98
Sene, Claude Strasbourg, FR 13 45

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