Polycationic quaternary ammonium polymer coatings for immobilizing biological samples
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United States of America Patent
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Dec 31, 2013
Grant Date -
Apr 6, 2006
app pub date -
Sep 22, 2005
filing date -
Sep 23, 2004
priority date (Note) -
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Abstract
The present invention is directed to a pre-coated substrate, such as a slide, that is useful for immobilizing a sample. The invention is further provides methods of preparing such pre-coated substrates and methods of analyzing biological samples immobilized on such pre-coated substrate. The substrate is coated with a polycationic polymeric coating material specifically selected such that that coated substrate exhibits increased stability and prolonged shelf-life. Preferred polymeric coating materials include allylic or vinylic polymers having cationic groups thereon and having no more than a small percentage of peptidic monomeric linkages, particularly polydiallyldimethylammonium (PDDA).
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