Anti-CD147 antibodies, methods and uses
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United States of America Patent
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Dec 31, 2013
Grant Date -
Aug 18, 2011
app pub date -
Aug 19, 2009
filing date -
Sep 29, 2008
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Abstract
The present invention provides antibodies immunospecific for human CD147 capable of blocking bioactivity of CD147 associated with malignant disease such as the stimulation of MMPs from fibroblast cells by tumor cells, the release of VEGF, and the promotion of angiogenesis. The antibodies of the present invention of are useful in treating malignant disease and those diseases in which CD147 activity is plays a pathogenic role, such as diseases of the eye, lung, and cardiovascular system.
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