Glycorandomization and production of novel novobiocin analogs

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United States of America Patent

PATENT NO 8618269
APP PUB NO 20120264924A1
SERIAL NO

13448811

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Abstract

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The present invention provides glycorandomized structures and combinatorial methods for rapidly generating a diverse library of glycorandomized structures, comprising incubating one or more aglycons and a pool of NDP-sugars in the presence of a glycosyltransferase. The glycosyltransferase may be one that is associated with or involved in production of natural secondary metabolites, or one which is putatively associated with or involved in production of natural secondary metabolites. The glycosyltransferase may show significant flexibility with respect to its NDP-sugar donors and/or its aglycons. NDP-sugar donors may be commercially available, or may be produced by utilizing mutant or wild type nucleotidyltransferases significant flexibility with respect to their substrates.

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Patent Owner(s)

Patent OwnerAddress
WISCONSIN ALUMNI RESEARCH FOUNDATIONMADISON WI

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Thorson, Jon Middleton, US 8 15

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