2-aryl-propionic acids and derivatives and pharmaceutical compositions containing them
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United States of America Patent
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Jan 7, 2014
Grant Date -
Aug 25, 2011
app pub date -
Sep 18, 2009
filing date -
Sep 18, 2008
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Abstract
The present invention relates to (R,S) 2-aryl-propionic acids and derivatives, their single enantiomer (S) and to pharmaceutical compositions containing them, which are used in the prevention and treatment of tissue damage due to the exacerbated recruitment of polymorphonucleated neutrophils (PIvTN leukocytes) at inflammation sites. The present invention provides compounds for use in the treatment of transient cerebral ischemia, bullous pemphigo, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and damages caused by ischemia and reperfusion.
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