Method for inducing a TRIF-bias

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United States of America Patent

PATENT NO 8629116
APP PUB NO 20110257113A1
SERIAL NO

13140930

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Abstract

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The use of a selected aminoalkyl glusoaminide 4-phosphate (AGP) CRX-547 to induce a TRIF biased response in a human system, which results in reduced levels of MyD88-dependent cytokines relative to the MyD88-dependent cytokines induced by its diastereomer AGP CRX-527.

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Patent Owner(s)

  • GLAXOSMITHKLINE BIOLOGICALS SA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bowen, William S Hamilton, US 3 0
Evans, Jay T Hamilton, US 13 60
Hutton, Melinda M Hamilton, US 3 0
Johnson, David A Hamilton, US 250 4062
Minns, Laurie A Shoreline, US 3 0

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