Methods for co-encapsulation of combination drugs and co-encapsulated combination drug product
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United States of America Patent
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Jan 28, 2014
Grant Date -
Sep 30, 2010
app pub date -
Mar 31, 2009
filing date -
Mar 31, 2009
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Abstract
This invention is for an improved process to co-encapsulate hydrophobic drugs and hydrophilic drugs in phospholipid liposomes. Non-toxic supercritical or near-critical fluids with/without polar cosolvents are utilized to solubilize phospholipid materials and hydrophobic drugs, and form uniform liposomes to encapsulate hydrophobic drugs and hydrophilic drugs.
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