KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy

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United States of America Patent

PATENT NO 8642010
APP PUB NO 20100003195A1
SERIAL NO

12480578

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Abstract

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The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD<1 μM), and dimer and multimeric constructs comprising these polypeptides.

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Patent Owner(s)

  • BRACCO SUISSE SA;DYAX CORPORATION

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Arbogast, Christophe Viuz-en-Sallaz, FR 12 212
Bussat, Philippe La Roche-sur-Foron, FR 91 1927
Dransfield, Daniel T Hanson, US 42 433
Fan, Hong PuDong, CN 36 342
Khurana, Sudha San Jose, US 8 81
Ladner, Robert C Ijamsville, US 96 10162
Linder, Karen E Kingston, US 53 1019
Marinelli, Edmund R Lawrenceville, US 49 595
Nanjappan, Palaniappa Princeton, US 50 614
Nunn, Adrian D Lambertville, US 46 645
Pillai, Radhakrishna K Cranbury, US 24 144
Pochon, Sibylle Troinex, CH 25 340
Ramalingam, Kondareddiar Dayton, US 62 926
Sato, Aaron K Richmond, US 45 721
Sexton, Daniel J Melrose, US 57 508
Shrivastava, Ajay Princeton, US 17 239
Song, Bo Princeton, US 91 438
Swenson, Rolf E Princeton, US 92 1241
Von, Wronski Mathew A Moorestown, US 20 298
Yan, Feng Grand-Lancy, CH 172 1951

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