Screening assay for agents that alter target of rapamycin activity

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United States of America Patent

PATENT NO 8642283
APP PUB NO 20060216776A1
SERIAL NO

11441650

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Abstract

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The present invention provides an assay for the identification of agents which can modulate TOR-mediated phosphorylation of substrate proteins. The assays of the invention utilize substrate proteins whose amino acid sequence contains the Ser/Thr motif recognized by TOR. Naturally occurring TOR which may be used in the methods of the invention include TOR isolated from a variety of species, particularly mammalian tissues.

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Patent Owner(s)

  • SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Abraham, Robert T San Diego, US 6 8

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