Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and platinum derivatives

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 8642580
APP PUB NO 20030180383A1
SERIAL NO

10311995

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Abstract

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Compounds which are α-halogenoacryloyl distamycin derivatives of formula (I) wherein R1 is a bromine or chlorine atom; R2 is a distamycin or distamycin-like framework as set forth in the specification; or a pharmaceutically acceptable salt thereof; are cytotoxic agents particularly effective in the treatment of tumors over expressing GSH/GSTs system and which are poorly responsive or even resistant to conventional antitumor therapies.

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Patent Owner(s)

Patent OwnerAddress
NERVIANO MEDICAL SCIENCES S R LVIALE PASTEUR 10 NERVIANO (MI) I-20014

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Beria, Italo Nerviano-Milan, IT 40 204
Cozzi, Paolo Milan, IT 41 137
Geroni, M Cristina Milan, IT 1 0

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