Restriction endonuclease enhanced polymorphic sequence detection
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United States of America Patent
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Feb 18, 2014
Grant Date -
May 10, 2012
app pub date -
Mar 26, 2008
filing date -
Mar 26, 2007
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Abstract
Provided is an improved method for the detection of specific polymorphic alleles in a mixed DNA population. The method comprises enriching the relative percentage of a given polymorphic allele that is exponentially amplifiable by PCR. Also provided are methods for selectively enriching target nucleic acid, for example, fetal nucleic acid in a maternal sample. In the case of detecting fetal nucleic acid in a maternal sample, a restriction enzyme is introduced that can discriminate between the alleles of a polymorphic site. Preferably, the maternal allele is digested and nucleic acid comprising the paternal allele is relatively enriched.
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