Metabolite biomarkers for the detection of esophageal cancer using NMR

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United States of America Patent

PATENT NO 8653006
APP PUB NO 20120142542A1
SERIAL NO

13226256

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Abstract

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Methods for the detection and screening of esophageal adenocarcinoma (EAC) patients and for the monitoring of EAC treatment using a panel or panels of small molecule metabolite biomarkers are disclosed. In other aspects, methods for detection and screening for the progression of high-risk conditions (BE and HGD) to EAC and to monitoring treatment using a panel or panels of small molecule metabolite biomarkers are disclosed. The biomarkers are sensitive and specific for the detection of EAC, and can also be used to classify Barrett's esophagus (BE) and high-grade dysplasia (HGD), which are widely regarded as precursors of EAC.

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Patent Owner(s)

Patent OwnerAddress
INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION518 INDIANA AVENUE INDIANAPOLIS IN 46204

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hammoud, Zane Northville, US 3 2
Raftery, M Daniel West Lafayette, US 10 17
Zhang, Jian West Lafayette, US 1504 17611

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