Substituted oxazole derivatives and their use as tyrosine kinase inhibitors
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United States of America Patent
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Feb 25, 2014
Grant Date -
May 3, 2012
app pub date -
Jan 5, 2012
filing date -
Apr 4, 2005
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Abstract
The present invention relates to novel compounds selected from substituted oxazole derivatives of formula (I) that selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant tyrosine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective c-kit, bcr-abl and Flt-3 inhibitors.
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