Method and device for the detection of mutations in isolated gene sequences of the low-density lipoprotein receptor (LDL-r) which is associated with familial hypercholesterolemia
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
Mar 11, 2014
Grant Date -
N/A
app pub date -
Jan 21, 2004
filing date -
Jan 28, 2003
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
The invention relates to extracorporeal methods of analyzing the presence or absence of mutations which cause familial hypercholesterolemia. The inventive methods describe the way in which said mutations can be detected using a DNA sample from an individual and comprising the following: chain reaction of the polymerase with primers which are complementary to the low-density lipoprotein receptor gene; analysis of the amplified product by sequencing; restriction analysis; single strand conformation polymorphism techniques; heteroduplex analysis and analysis of a device on top of a biochip glass support on which oligonucleotide probes are disposed, which can be used to detect the aforementioned mutations in the DNA.
First Claim
Family
International Classification(s)
Cited Art Landscape
Patent Citation Ranking
Advertisement
Advertisement
Advertisement
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully