Stable perfluorocarbon emulsion for use as an artificial oxygen carrier
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United States of America Patent
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Mar 18, 2014
Grant Date -
Dec 15, 2011
app pub date -
Dec 8, 2009
filing date -
Dec 8, 2008
priority date (Note) -
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Abstract
Perfluorocarbon emulsions having a high stability and good oxygen release are disclosed and described. These perfluorocarbon emulsions are typically for use as artificial oxygen carriers. The perfluorocarbon emulsions include a disperse phase of a perfluorocarbon and an emulsion stabilizer, and continuous phase. The emulsion stabilizer can primarily include a poly(ethylene oxide) block copolymer. These stabilized perfluorocarbon emulsions can be used in liquid and/or hydrogel phases of perfusion bioreactors or various other culture systems to enhance cell viability in thick tissue constructs, or as blood substitutes, although other applications may also be considered.
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