Detection of HBX/8P11 hybrid sequence in human hepatocellular carcinoma
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United States of America Patent
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Mar 25, 2014
Grant Date -
Mar 21, 2013
app pub date -
Aug 30, 2012
filing date -
Sep 1, 2011
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Abstract
The present invention provides a method for diagnosing a particular type of human hepatocellular carcinoma (HCC), HBx/8p11-positive HCC, in a subject by detecting the presence of a specific, non-naturally occurring polynucleotide sequence that indicates integration of a portion of the human hepatitis B virus (HBV) sequence into the human genome on chromosome 8 in the 8p11 integration region. A kit and device useful for such a method are also provided. In addition, the present invention provides a method for treating an HBx/8p11-positive HCC.
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