Purification of oligonucleotides

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United States of America Patent

PATENT NO 8680262
SERIAL NO

13421273

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Abstract

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A method for purifying a protected oligonucleotide comprising the steps of:

    a) providing a solution of the protected oligonucleotide in at least one solvent A having a boiling point below the boiling point of a solvent B,heating the solution at a temperature of at least 30° C. and below the boiling point of the at least solvent A,adding solvent B until precipitation of a material is visible in the solution, said solvent B being an alcohol having 1 to 6 C-atoms or a diol having 2 to 6 C-atoms,allowing the solution to cool down under stirring until formation of a supernatant and a residue,removing the supernatantorb) providing solvent B, said solvent B being an alcohol having 1 to 6 C-atoms or a diol having 2 to 6 C-atoms,heating solvent B at a temperature above 30° C. and below the boiling point of solvent B,adding a solution of a protected oligonucleotide in at least one solvent A until precipitation of a material is visible in the solution,allowing the solution to cool down under stirring until formation of a supernatant and a residue,removing the supernatant.

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Patent Owner(s)

Patent OwnerAddress
GIRINDUS AG51427 BERGISCH-GLADBACH

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Groessel, Olaf Halle/Westfalen, DE 1 0
Hohlfeld, Andreas Halle/Westfalen, DE 21 117
Lange, Meinhof Starzach-Felldorf, DE 1 0
Link, Fritz Bensberg, DE 11 73
Schoenberger, Andreas Mueden/Aller, DE 3 1

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