Genetic alterations in isocitrate dehydrogenase and other genes in malignant glioma

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United States of America Patent

PATENT NO 8685660
APP PUB NO 20110229479A1
SERIAL NO

13060191

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Abstract

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We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas.

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Patent Owner(s)

  • DUKE UNIVERSITY;THE JOHNS HOPKINS UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Angenendt, Philipp Hamburg, DE 10 72
Bigner, Darell Mebane, US 43 320
Jones, Sian Baltimore, US 25 81
Karchin, Rachel Towson, US 11 147
Kinzler, Kenneth W Baltimore, US 281 4740
Kuan, Chien-Tsun Cary, US 32 188
Leary, Rebecca J Baltimore, US 15 239
Lin, Jimmy Cheng-Ho Baltimore, US 13 67
Papadopoulos, Nickolas Towson, US 89 1058
Parmigiani, Giovanni Boston, US 14 95
Parsons, D Williams Bellaire, US 18 72
Riggins, Gregory J White Hall, US 20 148
Velculescu, Victor Dayton, US 54 605
Vogelstein, Bert Baltimore, US 323 6261
Yan, Hai Chapel Hill, US 83 884
Zhang, Xiaosong Baltimore, US 43 109

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