Genetic alterations in isocitrate dehydrogenase and other genes in malignant glioma
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United States of America Patent
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Apr 1, 2014
Grant Date -
Sep 22, 2011
app pub date -
Sep 3, 2009
filing date -
Sep 3, 2008
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Abstract
We found mutations of the R132 residue of isocitrate dehydrogenase 1 (IDH1) in the majority of grade II and III astrocytomas and oligodendrogliomas as well as in glioblastomas that develop from these lower grade lesions. Those tumors without mutations in IDH1 often had mutations at the analogous R172 residue of the closely related IDH2 gene. These findings have important implications for the pathogenesis and diagnosis of malignant gliomas.
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Patent Owner(s)
- DUKE UNIVERSITY;THE JOHNS HOPKINS UNIVERSITY
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Inventor(s)
Inventor Name | Address | # of filed Patents | Total Citations |
---|---|---|---|
Angenendt, Philipp | Hamburg, DE | 10 | 72 |
Bigner, Darell | Mebane, US | 43 | 320 |
Jones, Sian | Baltimore, US | 25 | 81 |
Karchin, Rachel | Towson, US | 11 | 147 |
Kinzler, Kenneth W | Baltimore, US | 281 | 4740 |
Kuan, Chien-Tsun | Cary, US | 32 | 188 |
Leary, Rebecca J | Baltimore, US | 15 | 239 |
Lin, Jimmy Cheng-Ho | Baltimore, US | 13 | 67 |
Papadopoulos, Nickolas | Towson, US | 89 | 1058 |
Parmigiani, Giovanni | Boston, US | 14 | 95 |
Parsons, D Williams | Bellaire, US | 18 | 72 |
Riggins, Gregory J | White Hall, US | 20 | 148 |
Velculescu, Victor | Dayton, US | 54 | 605 |
Vogelstein, Bert | Baltimore, US | 323 | 6261 |
Yan, Hai | Chapel Hill, US | 83 | 884 |
Zhang, Xiaosong | Baltimore, US | 43 | 109 |
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