Storage-stable, anti-microbial compositions including ceragenin compounds and methods of use
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United States of America Patent
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Apr 8, 2014
Grant Date -
May 3, 2012
app pub date -
Nov 3, 2011
filing date -
Nov 3, 2010
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Abstract
Storage-stable, anti-microbial compositions and products include a carrier and a ceragenin compound suspended in the carrier. Ceragenin compounds suspended in the carrier include a sterol backbone and a number of cationic groups attached to the sterol backbone via hydrolysable linkages. The carrier has a pH of 5.5 or less, which acts to stabilize the hydrolysable linkages and increase the shelf-life of the anti-microbial compositions and anti-microbial products. Nevertheless, the ceragenin compounds described herein are designed to break down relatively quickly (e.g., within about 5 days) if the pH environment of the ceragenin compounds is raised to about pH 6.5 or greater.
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