Relaxin polypeptides comprising non-naturally encoded amino acids

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United States of America

PATENT NO 8691940
SERIAL NO

13212101

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Abstract

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Modified relaxin polypeptides and their uses are provided. In one aspect, the disclosure provides a relaxin polypeptide comprising one or more non-naturally encoded amino acids. The polypeptide may be linked to a linker, polymer, or biologically active molecule. The serum half-life of the relaxin polypeptide may be enhanced relative to the unconjugated form. In another aspect, the disclosure provides methods of treating a patient having a disorder modulated by relaxin.

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Patent Owner(s)

  • AMBRX, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
De, Dios Kristine San Diego, US 11 184
Hewet, Ahma Chula Vista, US 2 61
Knudsen, Nick San Diego, US 47 1108
Kraynov, Vadim San Diego, US 43 902
Pinkstaff, Jason Encinitas, US 32 740
Sullivan, Lorraine San Diego, US 12 210

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