Amide based insulin prodrugs
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United States of America Patent
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Apr 15, 2014
Grant Date -
Oct 20, 2011
app pub date -
Dec 18, 2009
filing date -
Dec 19, 2008
priority date (Note) -
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Abstract
Prodrug formulations of insulin and insulin analogs are provided wherein the insulin peptide has been modified by an amide bond linkage of a dipeptide prodrug element. The prodrugs disclosed herein have extended half lives of at least 10 hours, and more typically greater than 2 hours, 20 hours and less than 70 hours, and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.
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