Nanotechnology formulation of poorly soluble compounds
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United States of America Patent
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Apr 22, 2014
Grant Date -
Mar 1, 2012
app pub date -
Aug 23, 2011
filing date -
Aug 24, 2010
priority date (Note) -
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Abstract
Embodiments of the present invention are directed to articles of manufacture, spheres having a diameter of 50 to 500 nanometers which contain poorly soluble drugs and methods of making such spheres. Embodiments of the present invention have particular application for the following drug candidates and closely related poorly soluble derivatives of such candidates: (i) indole hydrazinecarbothioamide [NSC 73306]; (ii) fenretinide (4HPR) [NSC 374551]; (iii) safingol [NSC 714503]; (iv) 17-allylamino demethoxygeldanamycin (17-AAG) [NSC 330507]; and (v) an aminoflavone drug [NSC 686288].
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