Synthesis of (phenylalkyloxy)phenyl-oxobutanoic acids

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United States of America Patent

PATENT NO 8703991
SERIAL NO

13127120

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A method for synthesizing (phenylalkyloxy)phenyl-oxobutanoic acid compounds is described. The corresponding (phenylalkyloxy)acylphenyl compound is halogenated, giving the alpha haloketone. The halide is displaced by the anion of a di-alkyl malonate to give a substituted malonic ester. Hydrolysis of the ester and decarboxylation of the diacid gives the desired product.

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  • WELLSTAT THERAPEUTICS CORPORATION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Hudspeth, James P San Diego, US 12 83
Wirth, David D Oak Ridge, US 34 391

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