Compositions of PD-1 antagonists and methods of use

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United States of America Patent

PATENT NO 8709416
SERIAL NO

13332164

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Abstract

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Methods of treating cancer and infectious diseases utilizing a treatment regimen comprising administering a compound that reduces inhibitory signal transduction in T cells, in combination with a potentiating agent, such as cyclophosphamide, to produce potent T cell mediated responses, are described. Compositions comprising the PD-1 antagonists and potentiating agents useful in the methods of the invention are also disclosed.

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Patent Owner(s)

  • MEDIMMUNE, LLC

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Langermann, Solomon Baltimore, US 41 1131
Liu, Linda Clarksville, US 35 1286

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