Chemically modified ligase cofactors, donors and acceptors

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 8728725
APP PUB NO 20110008788A1
SERIAL NO

12831212

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Provided herein are methods for ligation of polynucleotides containing modified ligation components, particularly modified ligase cofactors, modified acceptors and modified donors. The methods readily applied to ligation-based assays for detection of a nucleic acid sequence where the use of the modified cofactor improves discrimination between matched and mismatched templates. Furthermore, the use of the modified ligation components reduces or eliminates the ligation in the absence of nucleic acid template.

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Patent Owner(s)

Patent OwnerAddress
TRILINK BIOTECHNOLOGIES9955 MESA RIM ROAD SAN DIEGO CA 92121

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lebedev, Alexandre San Diego, US 15 151
Paul, Natasha San Diego, US 5 30
Shum, Jonathan Richmond, US 9 113
Zon, Gerald San Carlos, US 32 727

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