Consensus coding sequences of human breast and colorectal cancers

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United States of America Patent

PATENT NO 8741573
SERIAL NO

12377073

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Abstract

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Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention and monitoring.

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Patent Owner(s)

  • THE JOHNS HOPKINS UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Barber, Thomas Baltimore, US 27 195
Jones, Sian Baltimore, US 25 88
Kinzler, Kenneth W Baltimore, US 282 4776
Lin, Jimmy Baltimore, US 18 113
Mandelker, Diana Baltimore, US 5 5
Parsons, D Williams Baltimore, US 18 78
Sjoblom, Tobias Baltimore, US 8 17
Velculesu, Victor E Baltimore, US 1 5
Vogelstein, Bert Baltimore, US 324 6303
Wood, Laura D Baltimore, US 8 11

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