Identification of antigen or ligand-specific binding proteins
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United States of America Patent
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Jun 10, 2014
Grant Date -
Sep 10, 2009
app pub date -
Mar 4, 2009
filing date -
Mar 5, 2008
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Abstract
The present invention discloses novel methods for the generation, expression and screening of diverse collections of binding proteins such as antibodies or fragments thereof in vertebrate host cells in vitro, for the identification and isolation of ligand- or antigen-specific binding proteins. The methods disclosed herein allow the expression of diverse collections of binding proteins from at least one vector construct, which optionally can give rise to collections of diverse binding proteins upon transfer and expression into vertebrate host cells in situ.
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