Multi-layered gradient vaginal ring
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United States of America Patent
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Jun 17, 2014
Grant Date -
Jun 14, 2012
app pub date -
Apr 7, 2010
filing date -
Jul 21, 2009
priority date (Note) -
In Force
status (Latency Note)
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Abstract
Multi-layered vaginal rings 2 comprising silicone elastomers and pharmaceutically active ingredients are disclosed. The rings comprise a number of layers, at least one of which contains a pharmaceutically active ingredient, and each of which is a silicone elastomer. The multiple layers preferably are produced from these layers of different compositions, including an inner layer 4, a middle layer 5, and an outer layer 6. After extrusion and simultaneous curing, however, the ring 2 includes a contiguous body which comprises a continuous silicone body providing unimpeded diffusion of the pharmaceutically active ingredient from the inner layer (s) 4 to the outer layer (s) 6. Methods of producing these vaginal rings and of using them are also disclosed.
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Family
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