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United States of America Patent

PATENT NO 8759087
APP PUB NO 20100016553A1
SERIAL NO

12518439

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Abstract

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A target internalized within a cell (and a binding member that specifically binds thereto) can be identified in an efficient manner by segregating (or substantially segregating) genetic material encoding the binding member from genetic material encoding a binding member that binds to a target that is not internalized. This can be achieved by employing a display library of binding members having a genotype/phenotype linkage via a non-fusion protein format, whereby genetic material encoding non-in-ternalized targets can be segregated (or substantially segregated) without lysing the cells. Internalized genetic material subsequently can be isolated and amplified.

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Patent Owner(s)

Patent OwnerAddress
MORPHOSYS AG82152 PLANEGG

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Enzelberger, Markus Planegg, DE 18 274

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