methods for testing toxicity of substances using donated human organs or tissues
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United States of America Patent
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Jul 8, 2014
Grant Date -
Nov 20, 2008
app pub date -
May 18, 2007
filing date -
May 18, 2007
priority date (Note) -
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Abstract
Properties such as toxicity of substances may be determined by assaying properties, fates and effects of substances in an ex vivo metabolically active human organ or tissue under normothermic perfusion with a fluid containing a test substance. The data can be used as, for example, part of a submission to a government regulatory organization. Preferred methods use perfused endocrine gland organs or tissues to evaluate hormone or other bodily chemical disruption caused by substances and pre-donation diseased or injured organs or tissues.
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