Modified gram-negative bacteria for use as vaccines

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United States of America Patent

PATENT NO 8778655
SERIAL NO

13496007

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Abstract

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The invention relates to Gram-negative bacteria carrying an inactivated gene encoding a glycosyltransferase involved in the synthesis of the core of the LPS of said Gram-negative bacteria, wherein said inactivated gene results in the synthesis of a LPS having a modified core. These strains have an attenuated virulence but induce a humoral immunity sufficient for ensuring vaccination of the host.

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Patent Owner(s)

  • CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE);UNIVERSITE D'AIX-MARSEILLE;UNIVERSIDAD DE NAVARRA;UNIVERSITE DE LA MEDITERRANEE (AIX-MARSEILLE II);UNIVERSITE DE LA MEDITERRANEE—AIX MARSEILLE II

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Arce, Gorvel Vilma Marseilles Cedex, FR 2 7
Conde-Alvarez, Raquel Pamplona, ES 2 7
Gorvel, Jean-Pierre Marseilles Cedex, FR 4 10
Iriarte, Maite Pamplona, ES 2 7
Moriyon, Ignacio Pamplona, ES 2 7

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